Notice: Function _load_textdomain_just_in_time was called incorrectly. Translation loading for the wordpress-seo domain was triggered too early. This is usually an indicator for some code in the plugin or theme running too early. Translations should be loaded at the init action or later. Please see Debugging in WordPress for more information. (This message was added in version 6.7.0.) in /var/www/html/wp-includes/functions.php on line 6260 Why Do Most Polled Researchers Run Red Blood Cell Partitioning Studies with Plasma Protein Binding? | Contract Pharma

What are you searching for?

Sign in
Company Blog

Why Do Most Polled Researchers Run Red Blood Cell Partitioning Studies with Plasma Protein Binding?

Pharmacokinetic (PK) parameters of new drug candidates are traditionally determined by measuring drug concentration in plasma.

Pharmacokinetic (PK) parameters of new drug candidates are traditionally determined by measuring drug concentration in plasma. However, many compounds bind to or diffuse into red blood cells (RBCs), and considering RBCs comprise at least 99% of cellular space in blood, this can significantly impact clearance and cause inaccuracies in PK calculations.

That’s why the majority of polled researchers said that they regularly conduct Red Blood Cell Partitioning Studies. Evaluating potential drug sequestration in red blood cells in addition to plasma protein binding studies helps to prevent misinterpretation of pharmacokinetic data and the potential overestimation of a drug’s intrinsic clearance. In fact, the majority of polled researchers said they run the studies just to be thorough, with the 2nd most common reason being indicators based on the molecular properties of their compound. The vast majority of respondents also said that they perform these evaluations in the discovery/preclinical phase of development, which helps to avoid costly missteps and delays from having to run additional studies because of clinical results or requests from a regulatory agency.


Add us as a preferred source on Google

Get the latest Contract Pharma news, insights and analysis in your Google Search and AI experiences.

Add Contract Pharma as a preferred source on Google (opens in a new tab)

Keep Up With Our Content. Subscribe To Contract Pharma Newsletters